{"id":19,"date":"2015-08-31T05:27:24","date_gmt":"2015-08-31T05:27:24","guid":{"rendered":"http:\/\/biophotonics.bccrc.ca\/?page_id=19"},"modified":"2025-10-05T11:10:41","modified_gmt":"2025-10-05T18:10:41","slug":"publications","status":"publish","type":"page","link":"https:\/\/biophotonics.bccrc.ca\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Journal Articles<\/h2>\n\n\n
<\/a><\/form>

2025<\/h3>
\"Segmental<\/div>

Brace, Eric; Fung, Alicia; Tanskanen, Adrian; Jeanie Malone, Calum E. MacAulay; Lane, Pierre M.<\/p>

Segmental airway adenocarcinoma-simulating phantom for endoscopic near-infrared optical coherence tomography<\/a> Journal Article<\/span> <\/p>

In: <\/span>Journal of Biomedical Optics, <\/span>vol. 30, <\/span>iss. 10, <\/span>pp. 105002 , <\/span>2025<\/span>.<\/p>

Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span><\/p>

@article{Brace2025,
\r\ntitle = {Segmental airway adenocarcinoma-simulating phantom for endoscopic near-infrared optical coherence tomography},
\r\nauthor = {Eric Brace AND Alicia Fung AND Adrian Tanskanen AND Jeanie Malone, Calum E. MacAulay AND Pierre M. Lane},
\r\nurl = {https:\/\/doi.org\/10.1117\/1.JBO.30.10.105002, DOI
\r\nhttps:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2025\/10\/Brace-2025.pdf, PDF},
\r\nyear  = {2025},
\r\ndate = {2025-10-07},
\r\nurldate = {2025-10-07},
\r\njournal = {Journal of Biomedical Optics},
\r\nvolume = {30},
\r\nissue = {10},
\r\npages = {105002 },
\r\nabstract = {Significance: There is an unmet need for readily accessible imaging targets to verify whether devices can discriminate lesions from healthy tissue and identify sub-surface vasculature in the small airways.
\r\n
\r\nAim: Our aim is to develop a phantom that mimics human segmental airway adenocarcinoma in vivo for 1310 nm endoscopic optical coherence tomography (OCT) and angiography characterization.
\r\n
\r\nApproach: We develop phantoms using a mixture of agar, intralipid, and coconut oil cured in a 3D printed mold with embedded tubing to mimic vasculature. The parenchyma optical attenuation coefficient (OAC) is calibrated using optical transmission measurements from an agar and intralipid dilution series. Depth-resolved OAC histogram distributions, analysis of variance, and image quality are used to assess repeatability and biofidelity of these phantoms.
\r\n
\r\nResults: Transmission measurements show large increases in OAC when intralipid is cured with agar compared with water-intralipid dilutions. Representative phantom OACs show repeatability within 2.7% and match normal in vivo tissue measurements within 16%. Embedded lesion phantoms achieve imaging characteristics of in vivo adenocarcinoma. Fluid flow within embedded tubing is visualized with Doppler OCT.
\r\n
\r\nConclusions: The segmental airway phantoms demonstrate in vivo human imaging characteristics, including structural and optical markers of pathological progression\u2014providing a platform for imaging system characterization and optimization.},
\r\nkeywords = {},
\r\npubstate = {published},
\r\ntppubtype = {article}
\r\n}
\r\n<\/pre><\/div>
Close<\/a><\/p><\/div>
Significance: There is an unmet need for readily accessible imaging targets to verify whether devices can discriminate lesions from healthy tissue and identify sub-surface vasculature in the small airways.
\r\n
\r\nAim: Our aim is to develop a phantom that mimics human segmental airway adenocarcinoma in vivo for 1310 nm endoscopic optical coherence tomography (OCT) and angiography characterization.
\r\n
\r\nApproach: We develop phantoms using a mixture of agar, intralipid, and coconut oil cured in a 3D printed mold with embedded tubing to mimic vasculature. The parenchyma optical attenuation coefficient (OAC) is calibrated using optical transmission measurements from an agar and intralipid dilution series. Depth-resolved OAC histogram distributions, analysis of variance, and image quality are used to assess repeatability and biofidelity of these phantoms.
\r\n
\r\nResults: Transmission measurements show large increases in OAC when intralipid is cured with agar compared with water-intralipid dilutions. Representative phantom OACs show repeatability within 2.7% and match normal in vivo tissue measurements within 16%. Embedded lesion phantoms achieve imaging characteristics of in vivo adenocarcinoma. Fluid flow within embedded tubing is visualized with Doppler OCT.
\r\n
\r\nConclusions: The segmental airway phantoms demonstrate in vivo human imaging characteristics, including structural and optical markers of pathological progression\u2014providing a platform for imaging system characterization and optimization.<\/div>
Close<\/a><\/p><\/div>