{"id":230,"date":"2015-11-19T20:12:10","date_gmt":"2015-11-19T20:12:10","guid":{"rendered":"http:\/\/biophotonics.bccrc.ca\/?page_id=230"},"modified":"2025-09-29T14:01:15","modified_gmt":"2025-09-29T21:01:15","slug":"oral-cancer","status":"publish","type":"page","link":"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/oral-cancer\/","title":{"rendered":"Oral Cancer"},"content":{"rendered":"\n<p>\nImage-guided techniques for biopsy site selection and tumour boundary delineation have the potential to significantly improve the management of oral cancer.&nbsp;OCT can provide high-resolution 3-dimensional images of tissue in real time to distinguish morphological tissue features associated with neoplastic development.\n<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Optical Coherence Tomography (OCT)<\/h2>\n\n\n\n<p>Our <a href=\"http:\/\/biophotonics.bccrc.ca\/index.php\/research\/technologies\/oct\/\">OCT catheter<\/a> and swept-source instrumentation are\u00a0capable of wide-field <em>in vivo<\/em> imaging in the oral cavity.\u00a0We use a hand-held side-looking fiber-optic rotary pullback catheter that images very long tissue volumes \u2014 90 mm in the pullback direction, ~2 mm into the tissue, and ~2.5mm transverse to the pullback direction \u2014 providing a 90-by-2.5 mm enface footprint on the tissue surface. This instrument provides a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Normal versus Abnormal Oral Mucosa<\/h2>\n\n\n\n<p>The OCT sections below show normal (top) and abnormal (bottom) oral mucosa. The images are very wide (33 mm of pullback) and narrow (1.2 mm of tissue depth) and have been compressed in the horizontal dimension to facilitate display (28:1 aspect). The normal section shows the epithelium and submucosa as uniform intensity stratifications.<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"288\" src=\"http:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/normal_oral.jpg\" alt=\"\" class=\"wp-image-136\" srcset=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/normal_oral.jpg 1000w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/normal_oral-300x86.jpg 300w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/normal_oral-500x144.jpg 500w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p>\n\nThe&nbsp;abnormal section shows thickening of the epithelium, loss of visibility of the basement membrane, and irregular intensity stratification.\n\n<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide\"><a href=\"http:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/abnormal_oral.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"288\" src=\"http:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/abnormal_oral.jpg\" alt=\"\" class=\"wp-image-138\" srcset=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/abnormal_oral.jpg 1000w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/abnormal_oral-300x86.jpg 300w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2015\/09\/abnormal_oral-500x144.jpg 500w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n\n\n\n<p>Continue with <a href=\"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/cervical-cancer\/\" data-type=\"page\" data-id=\"287\">Cervical Cancer<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Image-guided techniques for biopsy site selection and tumour boundary delineation have the potential to significantly improve the management of oral cancer.&nbsp;OCT can provide high-resolution 3-dimensional images of tissue in real time to distinguish morphological tissue features associated with neoplastic development. Optical Coherence Tomography (OCT) Our OCT catheter and swept-source instrumentation are\u00a0capable of wide-field in vivo [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":260,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-230","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Oral Cancer - Optical Cancer Imaging Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/oral-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oral Cancer - Optical Cancer Imaging Lab\" \/>\n<meta property=\"og:description\" content=\"Image-guided techniques for biopsy site selection and tumour boundary delineation have the potential to significantly improve the management of oral cancer.&nbsp;OCT can provide high-resolution 3-dimensional images of tissue in real time to distinguish morphological tissue features associated with neoplastic development. 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