{"id":446,"date":"2016-01-07T00:45:11","date_gmt":"2016-01-07T00:45:11","guid":{"rendered":"http:\/\/biophotonics.bccrc.ca\/?page_id=446"},"modified":"2025-09-29T13:26:40","modified_gmt":"2025-09-29T20:26:40","slug":"chronic-obstructive-pulmonary-disease","status":"publish","type":"page","link":"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/chronic-obstructive-pulmonary-disease\/","title":{"rendered":"Chronic Obstructive Pulmonary Disease"},"content":{"rendered":"\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\nChronic Obstructive Pulmonary Disease (COPD)&nbsp;is the 4th leading cause of death worldwide. The number of deaths is projected to increase due to higher smoking rates and an aging population in many countries.&nbsp;COPD (also known as emphysema) results in chronic airflow limitation.&nbsp;The disease is preventable but there no cure.\n<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Visualization of Emphysema<\/h2>\n\n\n\n<p>\nOCT enables high-resolution imaging of airway structure. The video below illustrates the structural differences between normal (left) and emphysematous (right) airways. These virtual fly-through animations were rendered from volumetric OCT data acquired from corresponding&nbsp;airways in patients with and without emphysema. &nbsp;As we move distally further along the airway we pass the branch points of other airways. We also very clearly observe the destruction of the alveolar walls in the emphysematous airway.\n<\/p>\n<\/div>\n\n\n\n<figure class=\"wp-block-video alignwide\"><video autoplay controls loop muted preload=\"auto\" src=\"http:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/Normal-Emphysema.mp4\" playsinline><\/video><\/figure>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Airway Measurements<\/h2>\n\n\n\n<p>\nAs OCT imaging is a relatively new imaging modality for the airways, it was particularly important for our group to correlate OCT images with histology so we could understand what OCT could tell us about the small airways.\n<\/p>\n\n\n\n<div class=\"wp-block-group is-content-justification-center is-nowrap is-layout-flex wp-container-core-group-is-layout-23441af8 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image alignleft size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"267\" height=\"300\" src=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-oct-267x300.jpg\" alt=\"pig-airway-oct\" class=\"wp-image-469\" srcset=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-oct-267x300.jpg 267w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-oct.jpg 530w\" sizes=\"auto, (max-width: 267px) 100vw, 267px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image alignleft size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"266\" height=\"300\" src=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-pentachrome-266x300.jpg\" alt=\"pig-airway-pentachrome\" class=\"wp-image-468\" style=\"object-fit:cover\" srcset=\"https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-pentachrome-266x300.jpg 266w, https:\/\/biophotonics.bccrc.ca\/wp-content\/uploads\/2016\/01\/pig-airway-pentachrome.jpg 530w\" sizes=\"auto, (max-width: 266px) 100vw, 266px\" \/><\/figure>\n<\/div>\n\n\n\n<p>This is an example from a study we did with resected pig airways.\u00a0The contrast in OCT images is generated by local backscatter and the intensity in the images correlates with backscatter intensity.\u00a0By comparing the two images, we can identify the airway wall components in histology responsible for the stratified backscatter in the OCT image. <\/p>\n\n\n\n<p>Going from low backscatter in black to high backscatter in yellow, we see that cartilage (C) plates look very dark, the lamina propria (LP) is very bright, while the smooth muscle (SM) and epithelium (E) come in between the two.<\/p>\n\n\n\n<p>Continue with <a href=\"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/oral-cancer\/\" data-type=\"page\" data-id=\"230\">Oral Cancer<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Chronic Obstructive Pulmonary Disease (COPD)&nbsp;is the 4th leading cause of death worldwide. The number of deaths is projected to increase due to higher smoking rates and an aging population in many countries.&nbsp;COPD (also known as emphysema) results in chronic airflow limitation.&nbsp;The disease is preventable but there no cure. Visualization of Emphysema OCT enables high-resolution imaging [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":260,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-446","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chronic Obstructive Pulmonary Disease - Optical Cancer Imaging Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biophotonics.bccrc.ca\/index.php\/research\/applications\/chronic-obstructive-pulmonary-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chronic Obstructive Pulmonary Disease - Optical Cancer Imaging Lab\" \/>\n<meta property=\"og:description\" content=\"Chronic Obstructive Pulmonary Disease (COPD)&nbsp;is the 4th leading cause of death worldwide. 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